Cymbalta
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Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression.

Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful.

Important information

Do not take Cymbalta within 5 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms

To make sure Cymbalta is safe for you, tell your doctor if you have ever had:

liver or kidney disease; seizures or epilepsy; a bleeding or blood clotting disorder; high blood pressure; narrow-angle glaucoma; bipolar disorder (manic depression); or drug addiction or suicidal thoughts.

Fibromyalgia and chronic pain

A review of duloxetine found that it reduced pain and fatigue, and improved physical and mental performance compared to placebo.[25]

The U.S. Food and Drug Administration (FDA) regulators approved the drug for the treatment of fibromyalgia in June 2008.[26]

It may be useful for chronic pain from osteoarthritis.[27][28]

On November 4, 2010, the U.S. Food and Drug Administration approved duloxetine to treat chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain

Call your doctor at once if you have:

a light-headed feeling, like you might pass out; vision changes, eye pain or swelling, eye redness; easy bruising, unusual bleeding; painful or difficult urination; a seizure;

a manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep;


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